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KMID : 1034320100010010008
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Sleep Medicine Research
2010 Volume.1 No. 1 p.8 ~ p.14
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A Polysomnography Study of Snoring and Obstructive Sleep Apnea in Relation to Chronic Bronchitis
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Baik In-Kyung
Kim Je-Hyeong
Jung Ki-Hwan
Yoon Dae-Wui
Kim Jin-Young
Kim Se-Joong
Lee Sung-Yong
Shim Jae-Jeong
In Kwang-Ho
Kang Kyung-Ho
Yoo Se-Hwa
Lee Seung-Hoon
Shin Chol
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Abstract
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Background and Objective Reportedly, snoring is associated with chronic bronchitis. This association warrants further studies including polysomnographic evaluations because of few epidemiologic studies on the association. Via a polysomnography study, we evaluated the associations of snoring, obstructive sleep apnea, and systemic inflammation with chronic bronchitis among 442 participants from a population-based cohort.
Methods: At baseline, we assessed participants’ serum levels of C-reactive protein, a biomarker of systemic inflammation. Over a 5-year period, we conducted overnight polysomnography and identified any new cases of chronic bronchitis.
Results: After taking into account age, smoking, and other potential risk factors, the multivariate odds ratio (95% CI) for chronic bronchitis was 2.9 (95% CI, 1.3-6.4) for snorers with cumulative duration of snoring episodes ≥ 1 hour as compared with those snoring < 1 hour. This association did not change after further adjustment for the presence of apnea. Obstructive sleep apnea had no association with chronic bronchitis. A higher level of serum C-reactive protein was associated with chronic bronchitis (p value for trend < 0.05). In a joint analysis of snoring and C-reactive protein, longer cumulative duration of snoring episodes accompanied by systemic inflammation was associated with a 10-fold (95% CI, 2.9 to 37.4) increase in the multivariate odds of chronic bronchitis.
Conclusions: This polysomnography study provides additional data supporting the hypothesis that snoring is associated with chronic bronchitis implying that snoring-related local and systemic inflammation may play roles in the development of chronic bronchitis.
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KEYWORD
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Snoring, Obstructive sleep apnea, Chronic bronchitis, Polysomnography
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